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In composition-based mostly Digital screening approaches, semiflexible molecular docking is frequently picked to make certain computational efficiency, when the receptor and ligands are dealt with with rigidity and adaptability, respectively. simply because protein overall flexibility and chemical framework range are usually not considered, the prediction results of molecular docking based on diverse crystal structures of precisely the same target are quite diverse. Accordingly, a molecular docking strategy depending on multiple typical receptor conformations of the specified focus on may be a attractive comprise. Our earlier studies advised that the NBC design could combine the prediction success of different scoring capabilities and exhibited the ideal prediction ability [21, 22].

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